IMG_E1413

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  1. Diflucan can be a cost-effective alternative to more expensive antifungals when susceptibility is confirmed.

  2. Diflucan is not effective for primary treatment of fungal brain abscesses.

  3. Diflucan dosing in continuous renal replacement therapy must account for effluent rate.

  4. May unmask or exacerbate cutaneous lupus erythematosus.

  5. Primary renal excretion necessitates dose adjustment in patients with renal impairment.

  6. Not effective against Histoplasma in the central nervous system due to poor penetration (unlike itraconazole).

  7. Often the initial antifungal encountered by medical students, establishing the azole class.

  8. Oral bioavailability exceeds 90, making oral dosing as effective as IV for most indications.

  9. Diflucan is a critical part of the antifungal arsenal in resource-limited settings.

  10. Diflucan loading doses are used to achieve therapeutic levels rapidly in serious infections.