IMG_E1413

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  1. Single-dose therapy for vaginal yeast infection revolutionized outpatient management.

  2. Diflucan should be avoided in patients with known hypersensitivity to other azoles.

  3. Diflucan is a potent inhibitor of human CYP2C9 and CYP3A4, driving many drug interactions.

  4. Can be used in continuous renal replacement therapy; dosing depends on effluent rate.

  5. Diflucan exposure is a major risk factor for the development of azole-resistant candidiasis.

  6. Serves as a benchmark for in vitro susceptibility testing of newer antifungals.

  7. Diflucan has activity against many dermatophytes, supporting its use in tinea infections.

  8. The legacy of Diflucan is its transformation of systemic fungal infection management from inpatient to often outpatient care.

  9. Diflucan can increase phenytoin levels, risking toxicity.

  10. Diflucan is a potent inhibitor of human CYP2C9 and CYP3A4, driving many drug interactions.