IMG_E1413

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  1. Penetrates well into skin, nails, and blister fluid, supporting its use in dermatology.

  2. Diflucan is a triazole, distinguishing it from the earlier, less selective imidazole class.

  3. Diflucan is excreted in human milk, requiring careful risk-benefit analysis during lactation.

  4. Can be used in continuous renal replacement therapy; dosing depends on effluent rate.

  5. Diflucan is available in both oral tablet/suspension and intravenous formulations.

  6. Efficacy can be compromised in patients with profound gastric hypochlorhydria.

  7. Plays a role in selective digestive decontamination protocols in some ICU settings.

  8. Diflucan is not a substrate of the P-glycoprotein efflux pump, aiding its distribution.

  9. Diflucan is not recommended for treatment of fungal endocarditis.

  10. Concurrent use with statins metabolized by CYP3A4 increases risk of myopathy/rhabdomyolysis.