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Acquired resistance often involves upregulation of efflux pumps or target site mutations.
Significantly increases serum concentration of drugs like warfarin, phenytoin, and sulfonylureas.
The long half-life (~30 hours) enables convenient once-daily dosing regimens.
Can be administered via nasogastric tube as the oral suspension is well-absorbed.
Diflucan may interact with calcium channel blockers, potentiating effects.
Infusion-related reactions are rare, making rapid IV administration generally safe.
Diflucan should be avoided in patients with known hypersensitivity to other azoles.
Loading doses are used in serious infections to achieve steady-state concentrations rapidly.
Not recommended for empirical treatment of serious infections in critically ill patients.
Therapeutic drug monitoring is not routinely required but can be useful in specific scenarios.
Acquired resistance often involves upregulation of efflux pumps or target site mutations.
Significantly increases serum concentration of drugs like warfarin, phenytoin, and sulfonylureas.
The long half-life (~30 hours) enables convenient once-daily dosing regimens.
Can be administered via nasogastric tube as the oral suspension is well-absorbed.
Diflucan may interact with calcium channel blockers, potentiating effects.
Infusion-related reactions are rare, making rapid IV administration generally safe.
Diflucan should be avoided in patients with known hypersensitivity to other azoles.
Loading doses are used in serious infections to achieve steady-state concentrations rapidly.
Not recommended for empirical treatment of serious infections in critically ill patients.
Therapeutic drug monitoring is not routinely required but can be useful in specific scenarios.