IMG_E1413

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  1. Single-dose therapy for vaginal yeast infection revolutionized outpatient management.

  2. Alopecia is a reversible but distressing side effect reported with prolonged use.

  3. Diflucan can cause taste distortion (dysgeusia) as a side effect.

  4. Intrinsically resistant organisms include Candida krusei and the Mucorales order.

  5. Not reliably effective in fungal endocarditis, where fungicidal therapy is preferred.

  6. Penetrates well into skin, nails, and blister fluid, supporting its use in dermatology.

  7. Plays a role in selective digestive decontamination protocols in some ICU settings.

  8. Diflucan’s efficacy can be reduced by concomitant use of rifampin.

  9. Development of the IV formulation expanded use to critically ill and unable-to-swallow patients.

  10. Diflucan is a Schedule H/P drug in many countries, requiring a prescription.