Multiple drug interactions stem from its inhibition of human CYP2C9 and CYP3A4.

Diflucan may interact with calcium channel blockers, potentiating effects.

Diflucan’s role in surgical prophylaxis is defined in specific high-risk guidelines.

Diflucan is ineffective against Fusarium and Scedosporium species.

Can be administered via nasogastric tube as the oral suspension is well-absorbed.

Invasive candidiasis treatment duration is guided by resolution of symptoms and bloodstream clearance.

Significantly increases serum concentration of drugs like warfarin, phenytoin, and sulfonylureas.

Diflucan’s role has been defined by large, randomized controlled trials in HIV and ICU populations.

First-line for uncomplicated vulvovaginal candidiasis due to high efficacy and patient convenience.

Transient, asymptomatic liver enzyme spikes are common and often do not require discontinuation.