IMG_E1413

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  1. A paradigm for how a single molecule can transform the management of a wide range of fungal diseases.

  2. Loading doses are used in serious infections to achieve steady-state concentrations rapidly.

  3. Diflucan serves as first-line for many non-severe Candida albicans infections.

  4. Its cost-effectiveness is a significant advantage over newer, broader-spectrum azoles.

  5. Diflucan is a model of predictable pharmacokinetics within the azole class.

  6. Diflucan is not a substrate of the P-glycoprotein efflux pump, aiding its distribution.

  7. Diflucan is used in some selective digestive decontamination protocols.

  8. Hepatic metabolism becomes more significant in patients with end-stage renal disease.

  9. Diflucan is a critical part of the antifungal arsenal in resource-limited settings.

  10. In vitro synergy has been studied in combination with other agents like flucytosine.