IMG_E1413

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  1. Diflucan can increase phenytoin levels, risking toxicity.

  2. Often the initial antifungal encountered by medical students, establishing the azole class.

  3. Diflucan can cause taste distortion (dysgeusia) as a side effect.

  4. QTc interval prolongation is a rare but serious potential adverse effect.

  5. Primary renal excretion necessitates dose adjustment in patients with renal impairment.

  6. Protein binding is relatively low (~12), contributing to good tissue distribution.

  7. Diflucan is often used in pediatric antifungal therapy with weight-based dosing.

  8. Lacks reliable activity against Aspergillus species, a critical limitation in its spectrum.

  9. Diflucan can be considered for treatment of Malassezia folliculitis.

  10. Resistance is often associated with prior fluconazole exposure, a key epidemiologic factor.