IMG_E1413

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  1. Can be administered via nasogastric tube as the oral suspension is well-absorbed.

  2. Invasive candidiasis treatment duration is guided by resolution of symptoms and bloodstream clearance.

  3. Diflucan may deplete coenzyme Q10 with long-term use, a theoretical concern.

  4. Diflucan may be used for step-down therapy after initial echinocandin treatment for candidemia.

  5. Its high selectivity for fungal enzymes over human ones is key to its relatively low toxicity.

  6. Its water solubility is a distinct advantage over older imidazole antifungals.

  7. For cryptococcal meningitis suppression, Diflucan remains the gold standard maintenance agent.

  8. Diflucan should be avoided in patients with known hypersensitivity to other azoles.

  9. Concomitant use with calcium channel blockers can lead to excessive hypotension and edema.

  10. Not effective against Histoplasma in the central nervous system due to poor penetration (unlike itraconazole).