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seventh in male patients. Most of new patients are diagnosed with non-muscle invasive bladder cancer.
It usually courses with a favorable prognosis, although there
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muscle-invasive disease. The standard treatment for intermediate and high-risk patients is a transurethral resection of bladder tumor, complemented by intravesical therapy
with Bacillus Calmette-Guerin. EGFR immunoreactivity is present in about 50% of bladder cancers and
correlates with recurrence, time to recurrence,
and survival. 24). The combination was safe and well tolerated.
In vaccinated patients anti-EGF antibody titers increased during the first months of immunization and 80% of
patients developed a good anti-EGF antibody response.
Anti-EGF response was predominantly against the central region of the EGF molecule (loop
B). IgG1 and IgG4 subclasses were the most relevant among the IgG anti-EGF antibodies generated after vaccination. The EGF serum levels were undetectable after
six months of treatment. Vaccination with CIMAvax-EGF in combination with
intravesical BCG develops a significant inverse correlation between anti-EGF antibody
titers and baseline EGF serum concentration suggesting that
in this context, the combination allowed the development of
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